5 Facts you should know about

APDS

Respiratory Complications: APDS patients commonly present with recurrent sinopulmonary infections, chronic cough, bronchiectasis, and pneumonia due to impaired B cell function and defective antibody production

Chronic Lung Disease: Persistent lung infections and inflammation in APDS can lead to the development of chronic lung diseases such as bronchiectasis, bronchiolitis obliterans, and interstitial lung disease

Bronchiectasis: APDS patients are at increased risk of developing bronchiectasis, characterized by irreversible dilation and thickening of the bronchial walls, leading to impaired mucociliary clearance and recurrent infections

Recurrent Pneumonia: Recurrent bacterial pneumonia is a hallmark feature of APDS, often caused by bacteria such as Streptococcus pneumoniae and Haemophilus influenzae

Pulmonary Function Testing: Pulmonary function tests (PFTs), including spirometry and lung volumes, may reveal obstructive or restrictive patterns in APDS patients, reflecting airway obstruction, bronchiolitis, or interstitial lung involvement

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