5 Facts you should know about

Tenosynovial giant cell tumor (TGCT)

TGCT can be classified into two main subtypes:

Localized-type TGCT
Diffuse-type TGCT

Benign but Locally Aggressive: TGCTs are benign lesions. However, they can be locally aggressive and have a tendency to recur after surgical excision, especially the diffuse type

Symptoms: The most common symptoms are pain, swelling, and restricted movement in the affected joint. The knee is the most commonly involved site, but any joint can be affected

MRI: Magnetic resonance imaging (MRI) is the preferred imaging modality for detecting and characterizing TGCT. The tumors often appear as hypointense on T1-weighted images and hyperintense on T2-weighted images

Histopathology: Under the microscope, TGCTs are composed of a mixture of mononuclear cells and osteoclast-like giant cells. The presence of hemosiderin deposits and xanthoma cells can be seen in many cases

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