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Gardner syndrome
Gardner syndrome is a form of familial adenomatous polyposis (FAP) that is characterized by multiple colorectal polyps and various types of tumors
Prevalence
N/A
Age of Onset
ICD-10
D12.6
Inheritance
This condition does not appear to have a clear pattern of inheritance.
5 Facts you should know
FACT
Gardner syndrome is an autosomal dominant form of polyposis characterized by the presence of multiple polyps in the colon together with tumors outside the colon
FACT
The number of polyps increases with age, and hundreds to thousands of polyps can develop in the colon
FACT
Cancers related to Gardner syndrome commonly appear in the thyroid, liver, and kidneys
FACT
The countless polyps in the colon predispose to the development of colon cancer; if the colon is not removed, the chance of colon cancer is considered to be very significant
FACT
Polyps may also grow in the stomach, duodenum, spleen, kidneys, liver, mesentery, and small bowel
Interest over time
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Common signs & symptoms
Dental abnormalities
Fundic gland or adenomatous polyps of the stomach
Adenomatous polyps of the small intestines
Osteomas
(benign bone growths)
Congenital hypertrophy of the retinal pigment epithelium
(a flat, pigmented spot within the outer layer of the retina)
Benign skin abnormalities
such as epidermoid cysts, fibromas
Current treatments
Although there is no cure for Gardner syndrome, treatment and management options are available to reduce the risk of cancer. For example, affected people typically undergo regular screening for the various polyps and tumors associated with Gardner syndrome to permit early diagnosis and treatment. This screening regimen may include:
Sigmoidoscopy or colonoscopy
every one to two years, beginning at age ten to 12 years. Once polyps are detected, colonoscopy is recommended annually until colectomy (removal of colon).
EGD (esophagogastroduodenoscopy)
beginning by age 25 and repeated every one to three years.